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Disease Profile
Pneumocystis jirovecii pneumonia
Prevalence
Prevalence estimates on Rare Medical Network websites are calculated based on data available from numerous sources, including US and European government statistics, the NIH, Orphanet, and published epidemiologic studies. Rare disease population data is recognized to be highly variable, and based on a wide variety of source data and methodologies, so the prevalence data on this site should be assumed to be estimated and cannot be considered to be absolutely correct.
Prevalence estimates on Rare Medical Network websites are calculated based on data available from numerous sources, including US and European government statistics, the NIH, Orphanet, and published epidemiologic studies. Rare disease population data is recognized to be highly variable, and based on a wide variety of source data and methodologies, so the prevalence data on this site should be assumed to be estimated and cannot be considered to be absolutely correct.
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Age of onset
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ICD-10
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Inheritance
Autosomal dominant A pathogenic variant in only one gene copy in each cell is sufficient to cause an autosomal dominant disease.
Autosomal recessive Pathogenic variants in both copies of each gene of the chromosome are needed to cause an autosomal recessive disease and observe the mutant phenotype.
X-linked
dominant X-linked dominant inheritance, sometimes referred to as X-linked dominance, is a mode of genetic inheritance by which a dominant gene is carried on the X chromosome.
dominant X-linked dominant inheritance, sometimes referred to as X-linked dominance, is a mode of genetic inheritance by which a dominant gene is carried on the X chromosome.
X-linked
recessive Pathogenic variants in both copies of a gene on the X chromosome cause an X-linked recessive disorder.
recessive Pathogenic variants in both copies of a gene on the X chromosome cause an X-linked recessive disorder.
Mitochondrial or multigenic Mitochondrial genetic disorders can be caused by changes (mutations) in either the mitochondrial DNA or nuclear DNA that lead to dysfunction of the mitochondria and inadequate production of energy.
Multigenic or multifactor Inheritance involving many factors, of which at least one is genetic but none is of overwhelming importance, as in the causation of a disease by multiple genetic and environmental factors.
Not applicable
Other names (AKA)
Pneumocystis pneumonia; Pneumocystis carinii pneumonia (former)
Treatment
FDA-Approved Treatments
The medication(s) listed below have been approved by the Food and Drug Administration (FDA) as orphan products for treatment of this condition. Learn more orphan products.
- Atovaquone(Brand name: Mepron®) Manufactured by Glaxo Wellcome Inc.
FDA-approved indication: For the acute oral treatment of mild to moderate Pneumocystis carinii pneumonia (PCP) in patients who are intolerant to trimethoprim-sulfamethoxazole. Prevention of PCP in patients who are intolerant to trimethoprim-sulfamethoxazole.
National Library of Medicine Drug Information Portal - Pentamidine isethionate(Brand name: Nebupent®) Manufactured by APP Pharmaceuticals
FDA-approved indication: Prevention of Pneumocystis carinii pneumonia in patients at high risk of developing this disease.
National Library of Medicine Drug Information Portal
Medline Plus Health Information - Trimetrexate glucuronate(Brand name: Neutrexin®) Manufactured by Medimmune Oncology, Inc.
FDA-approved indication: Concurrent leucovorin administration as an alternative therapy for the treatment of moderate to severe PCP in immunocompromised patients who are intolerant of, or are refractory to, trimethoprim sulfamethoxazole.
National Library of Medicine Drug Information Portal
Medline Plus Health Information - Pentamidine isethionate(Brand name: Pentam 300®) Manufactured by APP Pharmaceuticals
FDA-approved indication: Treatment of Pneumocystis carinii pneumonia.
National Library of Medicine Drug Information Portal
Medline Plus Health Information