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5 Facts you should know about
WHIM syndrome
1
Its name is an acronym for its main clinical manifestations: warts, hypogammaglobulinemia, infections, and myelokathexis
2
Myelokathexis, sometimes known simply as kathexis, is a trapping or retention of immune cells in the bone marrow
3
The conditions are caused by mutations in the gene encoding the immune receptor CXC chemokine receptor 4 (CXCR4), causing it to be overactive
4
The first symptoms of the disorder usually present as recurring infections in early childhood, followed by the appearance of warts on various parts of the body
5
Susceptibility to HPV is disproportionate compared with other immunodeficiency conditions
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