5 Facts you should know about

Systemic mastocytosis

The most frequent symptoms associated with the disease include pruritis, flushing, itching, diarrhea, and anaphylaxis

The spectrum ranges from indolent SM, which is predominantly characterized by severe constitutional symptoms caused by mast cell degranulation and mediator release, to advanced SM, which is characterized by organ dysfunction and reduced survival due to mast cell infiltration

Across all forms of SM, the KIT D816V mutation is the primary driver of disease

The vast majority of patients have non-advanced (indolent or smoldering) SM, with debilitating symptoms that lead to a profound, negative impact on quality of life

Approximately 60%-70% of patients with advanced systemic mastocytosis have an associated neoplasm

See our full disease profile

Rare Immunology News