5 Facts you should know about

PLCG2-associated Antibody Deficiency and Immune Dysregulation (PLAID)

An allergic response to cold, called cold urticaria, is the most distinct symptom

The allergic response to cold likely results from abnormal activation of immune cells at low temperatures

Additionally, some individuals with PLAID can develop a burn-like rash at birth in areas most likely to be exposed to cold temperatures, such as the nose

Also typical are recurrent bacterial infections and an increased likelihood of developing autoimmune disorders

Another common symptom is a burning sensation in the throat when eating cold food

See our full disease profile

Rare Immunology News