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5 Facts you should know about
DOCK8 deficiency
1
It is the autosomal recessive form of hyperimmunoglobulin E syndrome
2
The signs and symptoms of DOCK8 deficiency are similar to the autosomal dominant form, STAT3 deficiency
3
DOCK8 deficient children often have eczema, respiratory and skin staphylococcus infections
4
The low number of T cells (T cell lymphopenia) and other lymphocytes appears to be responsible for the susceptibility to infections, and the poor humoral immunity is responsible for low response to vaccines
5
Children with DOCK8 deficiency do not tend to live long; sepsis is a common cause of death at a young age
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