5 Facts you should know about

BENTA Disease

BENTA (Benign Ethnic Neutropenia of the African) Disease is a benign condition predominantly found in individuals of African descent, characterized by persistently low levels of neutrophils in the blood without associated infections or clinical symptoms

Neutropenia in BENTA results from genetic variations affecting neutrophil production and survival, specifically the gene ELANE, although other genetic factors might contribute

Diagnosis involves evaluating neutrophil levels persistently below the reference range, excluding secondary causes of neutropenia, and genetic testing to identify mutations in the ELANE gene

Individuals with BENTA generally remain asymptomatic, with no increased susceptibility to infections; hence, treatment is usually unnecessary, focusing on monitoring and educating patients about potential risks during severe infections

Recognizing BENTA is crucial to differentiate it from other forms of neutropenia, ensuring appropriate management strategies and avoiding unnecessary interventions

See our full disease profile

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