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Disease Profile
Sarcoidosis
Prevalence estimates on Rare Medical Network websites are calculated based on data available from numerous sources, including US and European government statistics, the NIH, Orphanet, and published epidemiologic studies. Rare disease population data is recognized to be highly variable, and based on a wide variety of source data and methodologies, so the prevalence data on this site should be assumed to be estimated and cannot be considered to be absolutely correct.
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Age of onset
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ICD-10
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Inheritance
Autosomal dominant A pathogenic variant in only one gene copy in each cell is sufficient to cause an autosomal dominant disease.
Autosomal recessive Pathogenic variants in both copies of each gene of the chromosome are needed to cause an autosomal recessive disease and observe the mutant phenotype.
X-linked
dominant X-linked dominant inheritance, sometimes referred to as X-linked dominance, is a mode of genetic inheritance by which a dominant gene is carried on the X chromosome.
dominant X-linked dominant inheritance, sometimes referred to as X-linked dominance, is a mode of genetic inheritance by which a dominant gene is carried on the X chromosome.
X-linked
recessive Pathogenic variants in both copies of a gene on the X chromosome cause an X-linked recessive disorder.
recessive Pathogenic variants in both copies of a gene on the X chromosome cause an X-linked recessive disorder.
Mitochondrial or multigenic Mitochondrial genetic disorders can be caused by changes (mutations) in either the mitochondrial DNA or nuclear DNA that lead to dysfunction of the mitochondria and inadequate production of energy.
Multigenic or multifactor Inheritance involving many factors, of which at least one is genetic but none is of overwhelming importance, as in the causation of a disease by multiple genetic and environmental factors.
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Other names (AKA)
Sarcoid of Boeck; Schaumann's disease
Categories
Endocrine Diseases; Eye diseases; Heart Diseases;
Summary
Sarcoidosis is an inflammatory disease characterized by the development and growth of tiny lumps of
Symptoms
At the time of diagnosis, many people affected by sarcoidosis have a classic set of signs described as Lofgren’s Syndrome:[4]
- Fever
- Enlarged
lymph nodes - Swollen and painful joints
- Erythema nodosum
Because affected people frequently have lung involvement, other common symptoms include shortness of breath (dyspnea), a cough that won't go away, and chest pain.[1][5][4]
People with sarcoidosis may also experience: [1][5][3][4]
- Fatigue
- Weight loss
- Skin rashes, ulcers or discoloration
- Enlarged liver or spleen
- Vision problems, eye dryness or irritation
- Headaches,
seizures , or weakness on one side of the face - Aches and pains in the muscles and bones
- Abnormal heart beats
- Kidney stones
For more specific information, please visit the Foundation for Sarcoidosis Research's website. They offer an information page entitled "
This table lists symptoms that people with this disease may have. For most diseases, symptoms will vary from person to person. People with the same disease may not have all the symptoms listed. This information comes from a database called the Human Phenotype Ontology (HPO) . The HPO collects information on symptoms that have been described in medical resources. The HPO is updated regularly. Use the HPO ID to access more in-depth information about a symptom.